HZ05 |CAS:2097360-24-0 Probechem Biochemicals

Chemical Structure : HZ05

HZ05 (DHODH inhibitor HZ05)

Catalog No.: PC-63261Not For Human Use, Lab Use Only.

HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

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Biological Activity

HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

Physicochemical Properties

M.Wt	380.423
Formula	C21H21FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide

References

1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.

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HZ05 (DHODH inhibitor HZ05)

Biological Activity

Physicochemical Properties

References

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