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Chemical Structure : HZX-02-059
CAS No.: 2240205-30-3
Catalog No.: PC-47003Not For Human Use, Lab Use Only.
HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
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HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
HZX-02-059 exerts anti-proliferative action of DHL cells in a dose- and time-dependent manner, including Will-2, LR, and TMD8 cells (IC50=150-350 nM, 48 h).
HZX-02-059 induces a caspase-independent cell death in DHL cells. HZX-02-059 triggers non-apoptotic cell death of methuosis as a result of PIKfyve/TFEB inhibition.
HZX-02-059-induced cell cycle arrest is mechanistically associated with the inhibition of tubulin and mTOR/Myc axis.
HZX-02-059 (20 mg/kg, i.p.) suppresses growth of xenograft derived from DHL cells with a low systemic toxicity profile.
| M.Wt | 487.486 | |
| Formula | C27H20F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-methyl-3-((6-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)phenyl)-3-(trifluoromethyl)benzamide |
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1. Liying Feng, et al. Cell Death Discov. 2022 Jan 28;8(1):39.
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