Catalog No.: PC-47003Not For Human Use, Lab Use Only.
HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
HZX-02-059 (Methuosis inducer 1) is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
HZX-02-059 exerts anti-proliferative action of DHL cells in a dose- and time-dependent manner, including Will-2, LR, and TMD8 cells (IC50=150-350 nM, 48 h).
HZX-02-059 induces a caspase-independent cell death in DHL cells. HZX-02-059 triggers non-apoptotic cell death of methuosis as a result of PIKfyve/TFEB inhibition.
HZX-02-059-induced cell cycle arrest is mechanistically associated with the inhibition of tubulin and mTOR/Myc axis.
HZX-02-059 (20 mg/kg, i.p.) suppresses growth of xenograft derived from DHL cells with a low systemic toxicity profile.
