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Chemical Structure : Hexamethylene bisacetamide
CAS No.: 3073-59-4
Catalog No.: PC-61330Not For Human Use, Lab Use Only.
Hexamethylene bisacetamide (HMBA, NSC 95580) is a cell differentiation inducer that inhibits activation of NF-κB function, Akt and ERK/MAPK cascade.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 200 mg | $198 | In stock | |
| 1 g | Get quote |
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Hexamethylene bisacetamide (HMBA, NSC 95580) is a cell differentiation inducer that inhibits activation of NF-κB function, Akt and ERK/MAPK cascade.
Hexamethylene bisacetamide causes MEL cell differentiation by acting as a selective BD2 (bromodomain 2) inhibitor, kills Myc-induced lymphoma cells in vitro and in vivo.
Hexamethylene bisacetamide also is a small molecule inducer of HEXIM1 expression, inhibits the metastasis of breast cancer to lung in PyMT mice.
| M.Wt | 200.28 | |
| Formula | C10H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,6-Hexanebisacetamide |
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1. Ketchart W, et al. Oncogene. 2013 Aug 15;32(33):3829-39.
2. Nilsson LM, et al. Cancer Res. 2016 Apr 15;76(8):2376-83.
3. Dey A, et al. Cell Cycle. 2008 Dec;7(23):3759-67.
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