Hexamethylene bisacetamide (HMBA, NSC 95580) is a cell differentiation inducer that inhibits activation of NF-κB function, Akt and ERK/MAPK cascade.
Hexamethylene bisacetamide causes MEL cell differentiation by acting as a selective BD2 (bromodomain 2) inhibitor, kills Myc-induced lymphoma cells in vitro and in vivo.
Hexamethylene bisacetamide also is a small molecule inducer of HEXIM1 expression, inhibits the metastasis of breast cancer to lung in PyMT mice.
Physicochemical Properties
M.Wt
200.28
Formula
C10H20N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,6-Hexanebisacetamide
References
1. Ketchart W, et al. Oncogene. 2013 Aug 15;32(33):3829-39.
2. Nilsson LM, et al. Cancer Res. 2016 Apr 15;76(8):2376-83.
3. Dey A, et al. Cell Cycle. 2008 Dec;7(23):3759-67.
