HhAg1.5 (SAg1.5) | Hedgehog agonist | Probechem Biochemicals

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Chemical Structure : HhAg1.5

CAS No.: 612542-14-0

HhAg1.5 (SAG1.5, Hedgehog Agonist 1.5)

Catalog No.: PC-49040Not For Human Use, Lab Use Only.

HhAg1.5 (SAg1.5) is a small molecule Hedgehog agonist with EC50 of 1 nM, induces cilia translocation of SMO and GLI transcription factor activation, efficiently generates expandable liver stem cells (LSCs) in vitro.

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1 mg	$128	In stock
5 mg	$328	In stock
10 mg	$548	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HhAg1.5 (SAg1.5) is a small molecule Hedgehog agonist with EC50 of 1 nM, induces cilia translocation of SMO and GLI transcription factor activation, efficiently generates expandable liver stem cells (LSCs) in vitro.

Physicochemical Properties

M.Wt	526.043
Formula	C28H26ClF2N3OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-1-benzothiophene-2-carboxamide

References

1. Wang C, et al. Nat Commun. 2014 Jul 10;5:4355.

2. Liu J, et al. Onco Targets Ther. 2020 Nov 19;13:11957-11973.

3. Abhisek Mitra, et al. Transl Res. 2019 Mar;205:44-50.

4. Frank-Kamenetsky M, et al. J Biol. 2002;1:10.

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HhAg1.5 (SAG1.5, Hedgehog Agonist 1.5)

Biological Activity

Physicochemical Properties

References

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