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HlyU inhibitor CM14

Chemical Structure : HlyU inhibitor CM14

CAS No.: 588678-13-1

HlyU inhibitor CM14 (1025E12)

Catalog No.: PC-36127Not For Human Use, Lab Use Only.

HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.

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    Biological Activity

    HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.
    HlyU inhibitor CM14 (1025E12) reduces HlyU-dependent expression of virulence genes in V. vulnificus.
    HlyU inhibitor CM14 (1025E12) decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death.
    HlyU inhibitor CM14 (1025E12) also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.

    Physicochemical Properties

    M.Wt 345.372
    Formula C20H11NO3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(4-oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide

    References

    1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y.

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