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Chemical Structure : HlyU inhibitor CM14
Catalog No.: PC-36127Not For Human Use, Lab Use Only.
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.
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HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.
HlyU inhibitor CM14 (1025E12) reduces HlyU-dependent expression of virulence genes in V. vulnificus.
HlyU inhibitor CM14 (1025E12) decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death.
HlyU inhibitor CM14 (1025E12) also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.
| M.Wt | 345.372 | |
| Formula | C20H11NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y.
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