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Hsp70 inhibitor YK5

Chemical Structure : Hsp70 inhibitor YK5

CAS No.: 1268273-23-9

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Hsp70 inhibitor YK5 (YK5)

Catalog No.: PC-62469Not For Human Use, Lab Use Only.

YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.

    Physicochemical Properties

    M.Wt 432.503
    Formula C18H24N8O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(6-amino-2-((4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)pyrimidin-4-yl)acrylamide

    References

    1. Rodina A, et al. Chem Biol. 2013 Dec 19;20(12):1469-80.

    2. Rodina A, et al. Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL

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