Hsp90α-IN-12h

Chemical Structure : Hsp90α-IN-12h

Catalog No.: PC-72570Not For Human Use, Lab Use Only.

Hsp90α-IN-12h is the first Hsp90α-selective inhibitor with IC50 of 460 nM, exhibit 48-fold selectivity versus other Hsp90 isoforms.

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Biological Activity

Hsp90α-IN-12h is the first Hsp90α-selective inhibitor with IC50 of 460 nM, exhibit 48-fold selectivity versus other Hsp90 isoforms.
In NCI-H522 cells, Hsp90a-dependent substrates are readily degraded in the presence of Hsp90a-selective inhibitor.

Physicochemical Properties

M.Wt	375.486
Formula	C23H21NO2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((3-ethylphenyl)thio)-4-hydroxyphenyl)(isoindolin-2-yl)methanone

References

1. Sanket J Mishra, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551.

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Hsp90α-IN-12h

Biological Activity

Physicochemical Properties

References

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