I-0436650 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : I-0436650

I-0436650 (I0436650)

Catalog No.: PC-27630Not For Human Use, Lab Use Only.

I-0436650 is a potent, selective and allosteric inhibitor of human wild-type (wt) SHP2 with nanomolar potency, strongly inhibits ERK phosphorylation, exhibits antiproliferative activity in EGFR- and RAS-dependent cell lines.

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Biological Activity

I-0436650 is a potent, selective and allosteric inhibitor of human wild-type (wt) SHP2 with nanomolar potency, strongly inhibits ERK phosphorylation, exhibits antiproliferative activity in EGFR- and RAS-dependent cell lines.

Physicochemical Properties

M.Wt	479.99
Formula	C22H22ClN9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-((3-chloro-2-(1H-pyrazol-1-yl)pyridin-4-yl)thio)pyrazin-2-yl)-4'H,6'H-spiro[piperidine-4,5'-pyrrolo[1,2-b]pyrazol]-4'-amine

References

1. Ciammaichella A, et al. J Med Chem. 2026 Aug 13;69(15):18898-18914.

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I-0436650 (I0436650)

Biological Activity

Physicochemical Properties

References

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