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I-ABOPX

Chemical Structure : I-ABOPX

CAS No.: 112533-64-9

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I-ABOPX

Catalog No.: PC-20642Not For Human Use, Lab Use Only.

I-ABOPX is a potent, selective A3 adenosine receptor antagonist with high affinity for both the ovine (Ki=3 nM) and human (Ki=19 nM) A3 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    I-ABOPX is a potent, selective A3 adenosine receptor antagonist with high affinity for both the ovine (Ki=3 nM) and human (Ki=19 nM) A3 receptors.
    I-ABOPX (10 and 40 mg/kg i.v) blocked dose-dependently and surmountable the hypotensive response to APNEA in rats.

    Physicochemical Properties

    M.Wt 575.36
    Formula C23H22IN5O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(3-(4-amino-3-iodobenzyl)-2,6-dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid

    References

    1. Fozard JR, et al. Eur J Pharmacol. 1994 Feb 3;252(2):R5-6.

    2. Salvatore CA, et al. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10365-9.

    3. Linden J, et al. Mol Pharmacol. 1993 Sep;44(3):524-32.

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