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Chemical Structure : IACS-52825
Catalog No.: PC-20983Not For Human Use, Lab Use Only.
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.
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IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.
IACS-52825 shows no significant inhibition of the hERG channel or CYP P450 enzymes and no significant activities against an 80-member Eurofins CEREP panel of various ion channels and receptors or a 403-member Eurofins DiscoverX kinase panel.
IACS-52825 (orally once daily at 3, 10, or 30 mg/kg) dose-dependently reverses cisplatin-induced mechanical allodynia.
| M.Wt | 426.29 | |
| Formula | C16H13F7N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kang Le, et al. J Med Chem. 2023 Jul 12. doi: 10.1021/acs.jmedchem.3c00788.
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