Catalog No.: PC-20983Not For Human Use, Lab Use Only.
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.
IACS-52825 shows no significant inhibition of the hERG channel or CYP P450 enzymes and no significant activities against an 80-member Eurofins CEREP panel of various ion channels and receptors or a 403-member Eurofins DiscoverX kinase panel.
IACS-52825 (orally once daily at 3, 10, or 30 mg/kg) dose-dependently reverses cisplatin-induced mechanical allodynia.
