IC 87361 | DNA-PK inhibitor | Probechem Biochemicals

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Chemical Structure : IC 87361

IC 87361 (IC87361, IC-87361)

Catalog No.: PC-62995Not For Human Use, Lab Use Only.

IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β.
IC 87361 enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.

Physicochemical Properties

M.Wt	323.348
Formula	C19H17NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-hydroxy-7-morpholino-2-phenyl-4H-chromen-4-one

References

1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.

2. Shinohara ET, et al. Cancer Res. 2005 Jun 15;65(12):4987-92.

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IC 87361 (IC87361, IC-87361)

Biological Activity

Physicochemical Properties

References

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