Catalog No.: PC-49298Not For Human Use, Lab Use Only.
ICeD-1 is a potent DPP9 inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
ICeD-1 is a potent DPP9 inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
The efficacy of ICeD-1 is dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells.
ICeD-1 lowers the efficacious cell kill concentration of efavirenz to a clinically relevant dose at concentrations that do not result in complete DPP9 inhibition.
