Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ICeD-2
Catalog No.: PC-49297Not For Human Use, Lab Use Only.
ICeD-2 is a potent dipeptidyl peptidase 9 (DPP9) inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ICeD-2 is a potent dipeptidyl peptidase 9 (DPP9) inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
The efficacy of ICeD-2 is dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells.
ICeD-2 lowers the efficacious cell kill concentration of efavirenz to a clinically relevant dose at concentrations that do not result in complete DPP9 inhibition.
| M.Wt | 327.472 | |
| Formula | C20H29N3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Moore KP, et al. ACS Chem Biol. 2022 Aug 31. doi: 10.1021/acschembio.2c00515.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
