Chemical Structure : IDE inhibitor Ii1
CAS No.:
1093740-12-5
IDE inhibitor Ii1
(IDE inhibitor 1)
Catalog No.: PC-26433Not For Human Use, Lab Use Only.
IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IDE inhibitor Ii1 (IDE inhibitor 1) is a potent, selective inhibitor of insulin degrading enzyme (IDE) with Ki of 1.7 nM.
Ii1 exhibits a purely competitive mode of inhibition of the hydrolysis of insulin and Aβ.
Ii1 shows remarkably selective for IDE versus a wide range of conventional zinc-metalloproteases and representative members of other protease classes.
Ii1 inhibits the degradation of extracellular insulin dose-dependently, with IC50 of ~10 nM, in CHO cells overexpressing the human insulin receptor (IR).
Physicochemical Properties
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M.Wt
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743.82
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Formula
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C37H45N9O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-5-amino-4-((S)-2-((S)-5-guanidino-2-((R)-4-(hydroxyamino)-2-(naphthalen-2-ylmethyl)-4-oxobutanamido)pentanamido)-3-(1H-indol-3-yl)propanamido)-5-oxopentanoic acid
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References
1. Malcolm A Leissring, et al. PLoS One. 2010 May 7;5(5):e10504.
2. Takeshi Shiiki, et al. Biol Pharm Bull. 2025;48(11):1700-1707.
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