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Chemical Structure : IDN-7314
Catalog No.: PC-61354Not For Human Use, Lab Use Only.
IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
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IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
IDN-7314 also potently inhibited Fas-induced apoptosis of Jurkat cells with IC50 of 6.3 nM, demonstrates protective activity in the mouse model of Fas-induced hepatitis (ED50=0.7mg/kg, p.o.).
IDN-7314 synergistically inhibits tumor growth by activation of necroptosis and increased secretion of TNFα in a model of colon carcinoma combined with 5-FU.
| M.Wt | 549.382 | |
| Formula | C22H17F6N3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Oliver Metzig M, et al. Oncogene. 2016 Jun 30;35(26):3399-409.
2. Ueno H, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):199-202.
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