IHCH-3064 | A2AR/HDAC inhibitor | Probechem Biochemicals

Chemical Structure : IHCH-3064

IHCH-3064 (IHCH3064)

Catalog No.: PC-28314Not For Human Use, Lab Use Only.

IHCH-3064 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 2.2 nM (A2AR) and IC50 of 80.2 nM (HDAC1) respectively.

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Biological Activity

IHCH-3064 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 2.2 nM (A2AR) and IC50 of 80.2 nM (HDAC1) respectively.
IHCH-3185 shows good antiproliferative activity against tumor cell lines in vitro.
IHCH-3185 (60 mg/kg, bid) significantly inhibited mouse MC38 tumor growth with a tumor growth inhibition rate of 95.3%.

Physicochemical Properties

M.Wt	479.49
Formula	C25H21N9O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[2-[5-amino-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl]ethyl]-N-(2-aminophenyl)-

References

1. Wenzhong Yan, et al. J Med Chem. 2021 Nov 25;64(22):16573-16597.

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IHCH-3064 (IHCH3064)

Biological Activity

Physicochemical Properties

References

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