IHCH-3185 | A2AR/HDAC inhibitor | Probechem Biochemicals

Chemical Structure : IHCH-3185

IHCH-3185 (IHCH3185)

Catalog No.: PC-28312Not For Human Use, Lab Use Only.

IHCH-3185 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 7.6 nM (A2AR) and IC50 of 102.9 nM (HDAC1) respectively.

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Biological Activity

IHCH-3185 is a potent, dual-targeting adenosine A2A receptor (A2AR) antagonist and HDAC inhibitor with Ki of 7.6 nM (A2AR) and IC50 of 102.9 nM (HDAC1) respectively.
IHCH-3185 demonstrates broad-spectrum antiproliferative activity in vitro.
IHCH-3185 (20 mg/kg, oral) significantly inhibited CT26 and MC38 tumor growth in mice with tumor growth inhibition rates of 68.5% and 71.1%, respectively.

Physicochemical Properties

M.Wt	455.48
Formula	C24H21N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)oxy)ethyl)-N-(2-aminophenyl)benzamide

References

1. Wenzhong Yan, et al. J Med Chem. 2026 Mar 12;69(5):6038-6062.

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IHCH-3185 (IHCH3185)

Biological Activity

Physicochemical Properties

References

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