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You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Smoothened (Smo)-IHR-1
IHR-1

Chemical Structure : IHR-1

CAS No.: 548779-60-8

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IHR-1 (IHR 1;IHR1)

Catalog No.: PC-60380Not For Human Use, Lab Use Only.

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.

Physicochemical Properties

M.Wt 454.13
Formula C20H12Cl4N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)

References

1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9.

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