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IHR-Nac

Chemical Structure : IHR-Nac

CAS No.:

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IHR-Nac

Catalog No.: PC-60379Not For Human Use, Lab Use Only.

A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay; blocked Gli2 accumulation at the ciliary tip in response to SAG treatment, also blocks SAG-induced Gpr161 ciliary depletion.

Physicochemical Properties

M.Wt 476.738
Formula C22H16Cl3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2-acetamido-5-chloro-N-(4-(2,5-dichlorobenzamido)phenyl)benzamide

References

1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9.

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