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Chemical Structure : IHR-Nac
Catalog No.: PC-60379Not For Human Use, Lab Use Only.
A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay.
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A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay; blocked Gli2 accumulation at the ciliary tip in response to SAG treatment, also blocks SAG-induced Gpr161 ciliary depletion.
| M.Wt | 476.738 | |
| Formula | C22H16Cl3N3O3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9.
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