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Chemical Structure : IKAM-1
CAS No.: 2345648-37-3
Catalog No.: PC-38626Not For Human Use, Lab Use Only.
IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM.
IKAM-1 (Compound 39-100) selectively binds to MAP3K1 and MAP3K12, inhibits MAP3K1 with IC50 of 4.2 uM, does not inhibit IKKβ but selectively inhibits MAP3K1 with micromolar potency in PANC1 cell lysates.
IKAM-1 (Compound 39-100) inhibits MAP3K1-mediated IKKβ phosphorylation and reduced levels of p-IKKβ in with an IC50 value of 2.3 uM, inhibits the growth of PC lines with lowmicromolar potencies.
IKAM-1 (Compound 39-100) reduces activated IKKβ levels, inhibits tumor growth, and reduces metastasis in mice pancreatic tumor models.
| M.Wt | 441.26 | |
| Formula | C19H14BrFN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3-bromo-4-fluorophenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)urea |
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1. Napoleon JV, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119.
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