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Chemical Structure : IL17A inhibitor 10
Catalog No.: PC-49281Not For Human Use, Lab Use Only.
IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM.
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IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM.
IL17A inhibitor 10 exhibits an IC50 of 107 nM in FP assays when the unlabeled compound was pre-bound to IL17A before addition of FP probe.
IL17A inhibitor 10 inhibits IL17A/TNF stimulated cells in an IL17-dependent cell-based assay in which recombinant TNF and IL17A stimulated HeLa cells carrying an LCN2 promoter-driven luciferase reporter, with a much weaker TNF-only stimulated (IC50>50 uM).
| M.Wt | 854.960 | |
| Formula | C52H46N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eric R. Goedken, et al. Sci Rep. volume 12, Article number: 14561 (2022)
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