Catalog No.: PC-27000Not For Human Use, Lab Use Only.
IM-54 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 0.25 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis.
IM-54 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 0.25 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-54 does not show significant inhibitory activities against a panel of 467 kinases. IM-54 inhibited necrosis induced by oxidative stress (TBHP and H2O2), whereas Z-VAD did not. IM-54 did not inhibit apoptosis induced by anticancer drugs (actinomycin D, camptothecin, and etoposide) or physiological death ligand (Fas ligand), which was strongly inhibited by Z-VAD in each case. IM-54 shows therapeutic effect on ischemia-reperfusion injury.
Physicochemical Properties
M.Wt
297.36
Formula
C17H19N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(1H-indol-3-yl)-3-pentylamino-maleimide
References
1. Dodo K, et al. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3114-8.
