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IMD-0354

Chemical Structure : IMD-0354

CAS No.: 978-62-1

IMD-0354 (IMD 0354;IMD0354)

Catalog No.: PC-42418Not For Human Use, Lab Use Only.

IMD-0354 (IMD0354) is a potent IκB kinase β (IKKbeta) inhibitor, also is a potent inhibitor of glutamine uptake.

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Biological Activity

IMD-0354 (IMD0354) is a potent IκB kinase β (IKKbeta) inhibitor, also is a potent inhibitor of glutamine uptake.
IMD-0354 ameliorated airway hyperresponsiveness and reduced the numbers of bronchial eosinophils and mucus-producing cells in OVA-sensitized mice.
IMD-0354 inhibits NF-κB activation and reduces the numbers of bronchial eosinophils.
IMD-0354 inhibited IL-13 and IL-1β production, and it restored the production of IFN-γ. IMD-0354 attenuated mTOR signaling, suppressed two- and three-dimensional growth of melanoma cells, and induced cell-cycle arrest, autophagy, and apoptosis in melanoma.
IMD-0354 suppressed melanoma growth in a xenograft model.

Physicochemical Properties

M.Wt 383.6729
Formula C15H8ClF6NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO; 100 mM in Ethanol

Chemical Name/SMILES

Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-

References

1. Yongmei Feng, et al. Mol Cancer Ther. 2021 May;20(5):816-832.
2. Liu Y, et al. Biochem Biophys Res Commun. 2020 May 7;525(3):589-594.
3. Ogawa H, et al. Clin Exp Allergy. 2011 Jan;41(1):104-15.

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