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Chemical Structure : IMM-H007
CAS No.: 1221412-23-2
Catalog No.: PC-38551Not For Human Use, Lab Use Only.
IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo.
IMM-H007 (WS070117) (10 μM) inhibited cellular lipid accumulation induced by Oleic acid (0.25 mM).
IMM-H007 (WS070117) (0.1-10 uM) up-regulated AMPK signaling in OLA-induced steatosis in HepG2 cells, IMM-H007 (WS070117) (6 and 18 mg/kg) treatment also upregulated hepatic cellular AMPK phosphorylation in HFD fed hamsters.
IMM-H007 also activated AMPK and markedly suppressed AngII-induced TGF-β1 expression in human cardiac fibroblasts-adult ventricular, alleviated AngII-induced cardiac fibrosis by regulating AMPK-TGF-β1 signaling.
| M.Wt | 485.453 | |
| Formula | C22H23N5O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2',3',5'-Tri-O-acetyl-N(6)-(3-hydroxyphenyl) adenosine |
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1. Zhao Z, et al. Exp Biol Med (Maywood). 2012 Nov;237(11):1262-72.
2. Huang L, et al. J Lipid Res. 2015 May;56(5):986-97.
3. Shi H, et al. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391.
4. Wang MJ, et al. Eur J Pharmacol. 2019 Jun 5;852:167-178.
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