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Chemical Structure : IMP-1710
Catalog No.: PC-72219Not For Human Use, Lab Use Only.
IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.
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IMP-1710 (IMP1710) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 38 nM.
IMP-1710 demonstrated exquisite selectivity in a cross-screening against 20 DUBs.
IMP-1710 can profile activity of endogenous UCHL1 with excellent selectivity in cell types including endothelial cells (EA.hy926) and adenocarcinoma human alveolar basal epithelial cells (A549).
IMP-1710 demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=740 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.
IMP-1710 is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.
| M.Wt | 381.439 | |
| Formula | C23H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nattawadee Panyain, et al. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026.
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