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IMP-2373

Chemical Structure : IMP-2373

CAS No.:

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IMP-2373 (IMP2373)

Catalog No.: PC-21498Not For Human Use, Lab Use Only.

IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IMP-2373 is a highly targeted cyanopyrrolidine (CNPy) probe for pan-DUB to monitor DUB activity in physiologically relevant live cells.
    IMP-2373 is a potent broad-spectrum DUB enzyme inhibitor with minimal off-target cytotoxicity.
    IMP-2373 act as a competitive probe for in-cell target engagement by selective DUB inhibitors.
    IMP-2373 is a powerful and useful application of activity-based probe (ABP) in drug discovery and development.

    Physicochemical Properties

    M.Wt 360.42
    Formula C21H20N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1-cyanopyrrolidine-3-carbonyl)-N-(4-ethynylbenzyl)-1-methyl-1H-pyrrole-2-carboxamide

    References

    1. Daniel Conole, et al. Angew Chem Int Ed Engl. 2023 Nov 20;62(47):e202311190.

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