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Chemical Structure : IMT1
CAS No.: 2304621-31-4
Catalog No.: PC-72916Not For Human Use, Lab Use Only.
IMT1 (LDC195943) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IMT1 (LDC195943) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).
IMT1 binds to an allosteric binding site near the active centre cleft of POLRMT.
IMT1 efficiently impairs mtDNA transcription in a reconstituted recombinant system and cause a dose-dependent inhibition of mtDNA expression and OXPHOS in cell lines.
IMT1 demonstrates anti-tumour effects against the growth of cancer cells and the persistence of therapy-resistant cancer stem cells.
| M.Wt | 351.402 | |
| Formula | C21H21NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N,N-dimethyl-2-((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)oxy)propanamide |
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1. Bonekamp NA, et al. Nature. 2020 Dec;588(7839):712-716.
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