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IMT1B

Chemical Structure : IMT1B

CAS No.: 2304621-06-3

IMT1B (LDC203974)

Catalog No.: PC-72917Not For Human Use, Lab Use Only.

IMT1B (LDC203974) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).

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Biological Activity

IMT1B (LDC203974) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT).
IMT1B exhibits antiproliferative activity in A2780 cells with IC50 of 138 nM.
IMT1B is well-tolerated in mice, and suitable for in vivo use.
IMT1B does not cause OXPHOS dysfunction or toxicity in normal tissues, despite inducing a strong anti-tumour response in xenografts of human cancer cells.

Physicochemical Properties

M.Wt 473.88
Formula C24H21ClFNO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (4.74 mg/mL)

Chemical Name/SMILES

(S)-1-((R)-2-((4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)oxy)propanoyl)piperidine-3-carboxylic acid

References

1. Bonekamp NA, et al. Nature. 2020 Dec;588(7839):712-716.

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