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Chemical Structure : IMU1003
Catalog No.: PC-20175Not For Human Use, Lab Use Only.
IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation.
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IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation.
IMU1003 (10-20 uM) decreases Wnt-induced phenotypes in zebrafish embryos and HEK293 cells.
IMU1003 downregulates β-catenin in the nuclear fraction.
IMU1003 selectively suppresses proliferation of human cancer cell lines without an activating mutation in the Wnt/β-catenin signaling pathway (MDA-MB-231, IC50=10.4 uM).
IMU1003 suppresses the emergence of osimertinib-resistant colonies from gefitinib-resistant NSCLC.
| M.Wt | 324.33 | |
| Formula | C19H16O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yonezawa H, et al. Biochem Biophys Res Commun. 2020 Nov 12;532(3):440-445.
2. Katagiri H, et al. Biochem Biophys Res Commun. 2023 Feb 19;645:24-29.
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