Catalog No.: PC-45838Not For Human Use, Lab Use Only.
INCB3344 (INCB 3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.
INCB3344 (INCB 3344) is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively, in MCP-1 binding assays.
INCB3344 show no significant activity for murine CCR1 and murine CCR5 (IC50>1 uM), and a panel of >50 ion channels, transporters, chemokine receptors and other selected GPCRs.
INCB3344 inhibits macrophage influx in a mouse model of delayed-type hypersensitivity, significantly reduces disease in models of multiple sclerosis, and inflammatory arthritis.
