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Chemical Structure : INH-12
Catalog No.: PC-72079Not For Human Use, Lab Use Only.
INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV).
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INH-12 is a selective small-molecule HSD17B12 inhibitor with 70% inhibition of HSD17B12 activity to transform estrone (E1) into estradiol (E2) at 1 uM, reduces the replication of Flaviviridae viruses (HCV, DENV and ZIKV).
INH-12 shows no inhibitory activity against the C19 steroid metabolizing enzyme HSD17B3.
INH-12 dose-dependently inhibits DENV and ZIKV with mean EC50 values of 5.3 µM and 14.6 µM, respectively.
INH-12 shows potential of HSD17B12 inhibition as an antiviral target with a pan-Flaviviridae spectrum.
| M.Wt | 417.593 | |
| Formula | C28H35NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Siham Farhane, et al. Med Chem. 2011 Mar;7(2):80-91.
2. Bassim Mohamed, et al. Sci Rep. 2020 Mar 4;10(1):4040.
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