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Chemical Structure : INI-43
Catalog No.: PC-72015Not For Human Use, Lab Use Only.
INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783) is a small molecule that bind nuclear import receptor Karyopherin beta 1 (Kpnβ1), inhibits Kpnβ1-mediated nuclear import with anti-cancer activity.
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INI-43 (Inhibitor of Nuclear Import-43, ZINC20547783) is a small molecule that bind nuclear import receptor Karyopherin beta 1 (Kpnβ1), inhibits Kpnβ1-mediated nuclear import with anti-cancer activity.
INI-43 significantly diminished NFAT activation in a dosedependent manner (IC50=9.3 uM in HeLa cells).
INI-43 prevents transcription factor and Kpnβ1 access to the nucleus, and INI-43 treatment results in cancer cell death via a G2/M cell cycle arrest.
INI-43 treatment induces cancer cell cycle changes and apoptosis and inhibits tumour growth in vivo.
| M.Wt | 385.475 | |
| Formula | C22H23N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pauline J van der Watt, et al. Mol Cancer Ther. 2016 Apr;15(4):560-73.
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