Chemical Structure : IOI-214
CAS No.:
78349-84-5
IOI-214
(IOI 214)
Catalog No.: PC-21466Not For Human Use, Lab Use Only.
IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IOI-214 is a potent inhibitor of LPS-induced inflammatory cytokine production, prevent HF diet-induced NAFLD/MAFLD in vivo.
IOI-214 prevents LPS-induced inflammation in murine macrophages and hepatocytes in culture.
IOI-214 potently attenuates the robust LPS-induced upregulation of proinflammatory cytokine gene expression (Tnf, Ifnb1, Ccl2, Il1b, and Il6) in the cultured murine macrophages.
IOI-214 blocks HF diet-induced mesenteric fat accumulation without affecting HF diet-induced weight gain or subcutaneous fat accumulation.
IOI-214 (1 mg/kg, i.p.) ameliorates HF diet-induced hepatic steatosis.
IOI-214 mitigates HF diet-induced fasting hyperglycemia, without affecting fasting serum insulin, cholesterol or triglyceride levels, or glucose intolerance.
IOI-214 blocks HF diet-induced hepatic inflammatory cytokine and chemokine protein levels in vivo.
Physicochemical Properties
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M.Wt
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235.36
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Formula
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C12H13NS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-phenyl-3-propylthiazole-2(3H)-thione
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References
1. Kelly D McCall, et al. J Inflamm Res. 2023 Nov 16:16:5339-5366.
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