Chemical Structure : IOI-42
CAS No.:
438212-73-8
IOI-42
(hPEBP4 inhibitor IOI-42)
Catalog No.: PC-20703Not For Human Use, Lab Use Only.
hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.
IOI-42 promotes TRAIL-induced apoptosis of human prostate cancer cells.
IOI-42 (10 μM) enhances the inhibitory effect of TNF-α (20 ng/ml) on anchorage-independent growth of MCF-7 human breast cancer cells.
IOI-42 could impair the association of hPEBP4 with Raf-1 and MEK1 specifically and potentially and therefore block the suppressive effect of hPEBP4 on the TNF-α-induced activation of Raf-1/MEK1/ERK cascade.
IOI-42 is the first chemical inhibitor of hPEBP4, interacts with hPEBP4 in vitro, potentiates TNF-α/TRAIL-induced tumor cell apoptosis.
Physicochemical Properties
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M.Wt
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427.48
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Formula
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C24H17N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O)C1=CC=C(NC(NC(C2=CC(C3=CC=CC=C3)=NC4=CC=CC=C24)=O)=S)C=C1
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References
1. Qiu J, et al. J Biol Chem. 2010 Apr 16;285(16):12241-7.
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