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Chemical Structure : IOI-42
Catalog No.: PC-20703Not For Human Use, Lab Use Only.
hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.
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hPEBP4 inhibitor IOI-42 is a small molecule inhibitor of anti-apoptotic protein hPEBP4, potentiates TNF-α-mediated growth inhibition of MCF-7 breast cancer cells.
IOI-42 promotes TRAIL-induced apoptosis of human prostate cancer cells.
IOI-42 (10 μM) enhances the inhibitory effect of TNF-α (20 ng/ml) on anchorage-independent growth of MCF-7 human breast cancer cells.
IOI-42 could impair the association of hPEBP4 with Raf-1 and MEK1 specifically and potentially and therefore block the suppressive effect of hPEBP4 on the TNF-α-induced activation of Raf-1/MEK1/ERK cascade.
IOI-42 is the first chemical inhibitor of hPEBP4, interacts with hPEBP4 in vitro, potentiates TNF-α/TRAIL-induced tumor cell apoptosis.
| M.Wt | 427.48 | |
| Formula | C24H17N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qiu J, et al. J Biol Chem. 2010 Apr 16;285(16):12241-7.
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