Chemical Structure : IOWH-032
CAS No.:
1191252-49-9
IOWH-032
(iOWH-032, IOWH032, IOWH 032)
Catalog No. : PC-45456Not For Human Use, Lab Use Only.
IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis.
Packing Price Stock Quantity 25 mg $98 In stock 0 1 2 3 4 5 50 mg $138 In stock 0 1 2 3 4 5 100 mg $228 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4545601
Biological Activity
IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis.
IOWH-032 potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.
IOWH-032 inhibits the dual ATPase and helicase activities of SARS-CoV-2 Nsp13 at low micromolar concentrations.
IOWH-032 interacts with the RNA binding interface, leading to displacement of nucleic acid substrate, but not bound ATP.
IOWH-032 is selective for coronavirus Nsp13 over microbial helicases from other superfamilies.
Physicochemical Properties
M.Wt
545.1802
Formula
C22H15Br2N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-
References
1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol ACS Chem Biol
Contact Us
sales@probechem.com
