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IOWH-032

Chemical Structure : IOWH-032

CAS No.: 1191252-49-9

IOWH-032 (iOWH-032, IOWH032, IOWH 032)

Catalog No.: PC-45456Not For Human Use, Lab Use Only.

IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IOWH-032 is a potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis.
IOWH-032 potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis.
IOWH-032 inhibits the dual ATPase and helicase activities of SARS-CoV-2 Nsp13 at low micromolar concentrations.
IOWH-032 interacts with the RNA binding interface, leading to displacement of nucleic acid substrate, but not bound ATP.
IOWH-032 is selective for coronavirus Nsp13 over microbial helicases from other superfamilies.

Physicochemical Properties

M.Wt 545.1802
Formula C22H15Br2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-

References

1. Cui G, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.
2. Soper N, et al. ACS Chem Biol. 2024 Jul 9. doi: 10.1021/acschembio.4c00244.

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