Catalog No.: PC-42967Not For Human Use, Lab Use Only.
IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.
IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.
IOX1 is less potent against BBOX1 (IC50=196 uM); chelates to Fe(II) in the active site of 2OG oxygenases.
IOX1 suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.
Physicochemical Properties
M.Wt
189.1675
Formula
C10H7NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 24 mg/mL
Chemical Name/SMILES
5-Quinolinecarboxylic acid, 8-hydroxy-
References
1. Schiller R, et al. ChemMedChem. 2014 Mar;9(3):566-71.
2. Hu Q, et al. Int J Mol Med. 2016 Jan;37(1):189-96.
3. Mettananda S, et al. Haematologica. 2017 Mar;102(3):e80-e84.
4. Hopkinson RJ, et al. Chem Sci. 2013 Aug 1;4(8):3110-3117.
