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Chemical Structure : IOX1
CAS No.: 5852-78-8
Catalog No.: PC-42967Not For Human Use, Lab Use Only.
IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $348 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7.
IOX1 is less potent against BBOX1 (IC50=196 uM); chelates to Fe(II) in the active site of 2OG oxygenases.
IOX1 suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.
| M.Wt | 189.1675 | |
| Formula | C10H7NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 24 mg/mL |
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| Chemical Name/SMILES |
5-Quinolinecarboxylic acid, 8-hydroxy- |
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1. Schiller R, et al. ChemMedChem. 2014 Mar;9(3):566-71.
2. Hu Q, et al. Int J Mol Med. 2016 Jan;37(1):189-96.
3. Mettananda S, et al. Haematologica. 2017 Mar;102(3):e80-e84.
4. Hopkinson RJ, et al. Chem Sci. 2013 Aug 1;4(8):3110-3117.
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