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IPA

Chemical Structure : IPA

CAS No.: 200348-48-7

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IPA (Inhibitor of Priming Activity)

Catalog No.: PC-73090Not For Human Use, Lab Use Only.

IPA (Inhibitor of Priming Activity) is a small-molecule compound that binds Sec18 (Kd=3.84 uM) and blocks SNARE activation, inhibits vacuole fusion at the SNARE priming stage with IC50 of 50 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IPA (Inhibitor of Priming Activity) is a small-molecule compound that binds Sec18 (Kd=3.84 uM) and blocks SNARE activation, inhibits vacuole fusion at the SNARE priming stage with IC50 of 50 uM.
    IPA blocks SNARE priming and competes for phosphatidic acid (PA) binding to Sec18.
    IPA more potently and specifically inhibits NSF/Sec18 activity than does N-ethylmaleimide.
    IPA is a helpful chemical tool to further elucidate SNARE-priming dynamics.

    Physicochemical Properties

    M.Wt 394.379
    Formula C22H18O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-methyl-3-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

    References

    1. Sparks RP, et al. J Biol Chem. 2019 Nov 15;294(46):17168-17185.

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