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Chemical Structure : IQ-1
CAS No.: 331001-62-8
Catalog No.: PC-42676Not For Human Use, Lab Use Only.
A small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $378 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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IQ-1 is a small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.
IQ-1 decreases phosphorylation of p300 at Ser-89 and disrupts β-catenin/p300 interaction.
IQ-1 prevents β-catenin coactivator switching from CBP to p300, maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner.
| M.Wt | 362.42498 | |
| Formula | C21H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Acetamide, 2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene) |
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1. Miyabayashi T, et al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668-73.
2. Rieger ME, et al. J Biol Chem. 2016 Mar 18;291(12):6569-82.
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