Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Beta-catenin-IQ-1
IQ-1

Chemical Structure : IQ-1

CAS No.: 331001-62-8

IQ-1 (p300/β-catenin inhibitor IQ1)

Catalog No.: PC-42676Not For Human Use, Lab Use Only.

A small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.

Packing Price Stock Quantity
10 mg $78 In stock
25 mg $128 In stock
50 mg $218 In stock
100 mg $378 In stock
200 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IQ-1 is a small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.
IQ-1 decreases phosphorylation of p300 at Ser-89 and disrupts β-catenin/p300 interaction.
IQ-1 prevents β-catenin coactivator switching from CBP to p300, maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner.

Physicochemical Properties

M.Wt 362.42498
Formula C21H22N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

Acetamide, 2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)

References

1. Miyabayashi T, et al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668-73.

2. Rieger ME, et al. J Biol Chem. 2016 Mar 18;291(12):6569-82.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: