Chemical Structure : IRBM-Z-2
CAS No.:
3014840-61-7
IRBM-Z-2
Catalog No.: PC-26057Not For Human Use, Lab Use Only.
IRBM-Z-2 is a potent, non-competitive, allosteric inhibitor of ZIKV NS3 protease with binding KD of 21 nM (ZIKV NS2B-NS3 protease) and biochemical IC50 of 42 nM, potently inhibits both ZIKV viral replication (IC50=25 nM) and infectivity of ZIKV (CPE IC50=16 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IRBM-Z-2 is a potent, non-competitive, allosteric inhibitor of ZIKV NS3 protease with binding KD of 21 nM (ZIKV NS2B-NS3 protease) and biochemical IC50 of 42 nM, potently inhibits both ZIKV viral replication (IC50=25 nM) and infectivity of ZIKV (CPE IC50=16 nM).
IRBM-Z-2 exhibits antiviral activity against additional ZIKV strains, including Padova and H/PF/2013, in human HuH-7 cells with apparent IC50 values ranging from 6 to 20 nM.
IRBM-Z-2 displays inhibitory activity against other orthoflavivirus proteases, such as DENV2 and WNV, with potencies ranging from nanomolar to low micromolar in both biochemical and cell-based assays.
IRBM-Z-2 (100 mg/kg, i.p.) caused rapid and marked antiviral activity in mouse models of ZIKV infection.
Physicochemical Properties
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M.Wt
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469.43
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Formula
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C22H18F3N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Urea, N-[3-[[5-(4,6-dimethyl-5-pyrimidinyl)-2-pyridinyl]methyl]-1,2,3-oxadiazolium-5-yl]-N′-[3-(trifluoromethyl)phenyl]-, inner salt
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References
1. Ontoria JM, et al. Nat Commun. 2026 Feb 10;17(1):1439.
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