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Chemical Structure : IRE1α inhibitor 16
Catalog No.: PC-22296Not For Human Use, Lab Use Only.
IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.
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IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.
IRE1α inhibitor 18 is selective in kinase screens.
| M.Wt | 615.15 | |
| Formula | C32H31ClN6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Paul E Harrington, et al. ACS Med Chem Lett. 2014 Sep 24;6(1):68-72.
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