IRE1α inhibitor 16 | IRE1α inhibitor

Chemical Structure : IRE1α inhibitor 16

IRE1α inhibitor 16 (Amgen IRE1α inhibitor 16)

Catalog No.: PC-22296Not For Human Use, Lab Use Only.

IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.

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Biological Activity

IRE1α inhibitor 18 is a potent, selective and allosteric inhibitor of IRE1α endonuclease activity with enzyme IC50 of 13 nM, cellular IRE1α IC50 of 99 nM in XBP1-Luc cellular assays.
IRE1α inhibitor 18 is selective in kinase screens.

Physicochemical Properties

M.Wt	615.15
Formula	C32H31ClN6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[3-[2-[(trans-4-Aminocyclohexyl)amino]-4-pyrimidinyl]-2-pyridinyl]oxy]-3-methyl-1-naphthalenyl]-2-chlorobenzenesulfonamide

References

1. Paul E Harrington, et al. ACS Med Chem Lett. 2014 Sep 24;6(1):68-72.

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IRE1α inhibitor 16 (Amgen IRE1α inhibitor 16)

Biological Activity

Physicochemical Properties

References

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