Catalog No.: PC-61358Not For Human Use, Lab Use Only.
IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).
IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).
IRES-J007 significantly reduces tumor growth of GBM xenografts in mice.
IRES-J007 markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
