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IRF5 inhibitor N5-1

Chemical Structure : IRF5 inhibitor N5-1

CAS No.: 2088834-66-4

IRF5 inhibitor N5-1 (PRRVRLK)

Catalog No.: PC-72047Not For Human Use, Lab Use Only.

IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.

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Purity & Documentation Purity: 98.18% (HPLC) Select Batch:

Biological Activity

IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.
IRF5 inhibitor N5-1 binds to endogenous IRF5, but not IRF3 or IRF7, in human primary monocytes.
IRF5 inhibitor N5-1 significantly reduced R848-induced IRF5 nuclear translocation in monocytes.
IRF5 inhibitor N5-1 binds to the C-terminal IAD of inactive IRF5 monomer and inhibits phosphorylation of Ser462, readily enters primary immune cells to inhibit R848-induced IRF5 nuclear translocation with low associated toxicity.
IRF5 inhibitor N5-1 is a potent inhibitor of TLR7-induced IRF5 nuclear translocation in monocytes and B cells, selectively inhibits IRF5-mediated inflammatory cytokine expression in PBMCs.
IRF5 inhibitor N5-1 attenuated IL-6 production and IRF5 hyperactivation in NZB/W F1 mice, and reducedkidney pathology and increased overall survival in NZB/W F1 mice from spontaneous onset of lupus and mortality.

Physicochemical Properties

M.Wt 924.15
Formula C40H77N17O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Prolyl-L-arginyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-lysine

References

1. Su Song, et al. J Clin Invest. 2020 Dec 1;130(12):6700-6717.

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