Chemical Structure : IRF5 inhibitor N5-1
CAS No.: 2088834-66-4
Catalog No.: PC-72047Not For Human Use, Lab Use Only.
IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $138 | In stock | |
10 mg | $218 | In stock | |
25 mg | $368 | In stock | |
50 mg | $558 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
IRF5 inhibitor N5-1 (PRRVRLK) is a cell permeable, IRF5 peptide mimetic that selectively bind to and stabilizes the inactive IRF5 monomer with KD of 98.8 nM.
IRF5 inhibitor N5-1 binds to endogenous IRF5, but not IRF3 or IRF7, in human primary monocytes.
IRF5 inhibitor N5-1 significantly reduced R848-induced IRF5 nuclear translocation in monocytes.
IRF5 inhibitor N5-1 binds to the C-terminal IAD of inactive IRF5 monomer and inhibits phosphorylation of Ser462, readily enters primary immune cells to inhibit R848-induced IRF5 nuclear translocation with low associated toxicity.
IRF5 inhibitor N5-1 is a potent inhibitor of TLR7-induced IRF5 nuclear translocation in monocytes and B cells, selectively inhibits IRF5-mediated inflammatory cytokine expression in PBMCs.
IRF5 inhibitor N5-1 attenuated IL-6 production and IRF5 hyperactivation in NZB/W F1 mice, and reducedkidney pathology and increased overall survival in NZB/W F1 mice from spontaneous onset of lupus and mortality.
M.Wt | 924.15 | |
Formula | C40H77N17O8 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
L-Prolyl-L-arginyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-lysine |
1. Su Song, et al. J Clin Invest. 2020 Dec 1;130(12):6700-6717.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright