ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα).
ISA-2011B exhibits the highest binding affinity to PIP5K1α, and to MARK1 and MARK4 as well.
ISA-2011B targets PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways.
ISA-2011B significantly inhibits growth of tumor cells in xenograft mice.
