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Chemical Structure : ISA-2011B
CAS No.: 1395347-24-6
Catalog No.: PC-45095Not For Human Use, Lab Use Only.
ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα).
ISA-2011B exhibits the highest binding affinity to PIP5K1α, and to MARK1 and MARK4 as well.
ISA-2011B targets PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways.
ISA-2011B significantly inhibits growth of tumor cells in xenograft mice.
| M.Wt | 423.849 | |
| Formula | C22H18ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 57 mg/mL |
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| Chemical Name/SMILES |
5H-1,3-Dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione, 5-(5-chloro-1H-indol-3-yl)-8,9,10a,11-tetrahydro-9-methyl-, (5S,10aS) |
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1. Semenas J, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98.
2. Kunkl M, et al. Front Immunol. 2017 Apr 26;8:502.
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