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ISO-1

Chemical Structure : ISO-1

CAS No.: 478336-92-4

ISO-1 (ISO 1;ISO1;MIF Antagonist)

Catalog No.: PC-45038Not For Human Use, Lab Use Only.

ISO-1 is a potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with IC50 of 7 uM.

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Biological Activity

ISO-1 is a potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with IC50 of 7 uM.
ISO-1 significantly inhibits the cytokine activity in vitro, inhibits TNF release from macrophages isolated from LPS-treated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.
ISO-1 is the first small molecule inhibitor of MIF proinflammatory activities with therapeutic implications.

Physicochemical Properties

M.Wt 235.2359
Formula C12H13NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 36 mg/mL

Chemical Name/SMILES

5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester

References

1. Lubetsky JB, et al. J Biol Chem. 2002 Jul 12;277(28):24976-82.

2. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4.

3. Adamali H, et al. Am J Respir Crit Care Med. 2012 Jul 15;186(2):162-9.

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