ISO-66 |CAS:1819996-72-9 Probechem Biochemicals

Chemical Structure : ISO-66

ISO-66 (ISO66)

Catalog No.: PC-63118Not For Human Use, Lab Use Only.

ISO-66 is a novel, highly stable, small-molecule MIF inhibitor that inhibits MIF tautomerase activity with IC50 of 1.4 uM.

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Biological Activity

ISO-66 is a novel, highly stable, small-molecule MIF inhibitor that inhibits MIF tautomerase activity with IC50 of 1.4 uM.
ISO-66 enhances specific and non-specific anticancer immune responses, decreases tumor burden in melanoma or colon cancer mice.
ISO-66 is an analog of ISO-1 with improved characteristics.

Physicochemical Properties

M.Wt	237.23
Formula	C12H12FNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propanone,1-[3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]

References

1. Ioannou K, et al. Int J Oncol. 2014 Oct;45(4):1457-68.

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ISO-66 (ISO66)

Biological Activity

Physicochemical Properties

References

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