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Chemical Structure : IU-1
CAS No.: 314245-33-5
Catalog No.: PC-61234Not For Human Use, Lab Use Only.
IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | $868 | In stock | |
| 1 g | Get quote |
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IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
IU-1 (USP14 inhibitor IU1) displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.).
IU-1 (USP14 inhibitor IU1) enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.
| M.Wt | 300.377 | |
| Formula | C18H21FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone |
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1. Lee BH, et al. Nature. 2010 Sep 9;467(7312):179-84.
2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.
3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.
4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.
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