IU-1 |CAS:314245-33-5 Probechem Biochemicals

Chemical Structure : IU-1

CAS No.: 314245-33-5

IU-1 (USP14 inhibitor IU1)

Catalog No.: PC-61234Not For Human Use, Lab Use Only.

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.

Packing	Price	Stock
25 mg	$168	In stock
100 mg	$458	In stock
250 mg	$868	In stock
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Biological Activity

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM.
IU-1 (USP14 inhibitor IU1) displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.).
IU-1 (USP14 inhibitor IU1) enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.

Physicochemical Properties

M.Wt	300.377
Formula	C18H21FN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone

References

1. Lee BH, et al. Nature. 2010 Sep 9;467(7312):179-84.

2. Nag DK, et al. Virus Res. 2012 Apr;165(1):103-6.

3. Lahaie N, et al. J Biol Chem. 2016 Mar 25;291(13):7156-70.

4. Min JW, et al. J Neurochem. 2017 Mar;140(5):826-833.

IU-1 (USP14 inhibitor IU1)

Biological Activity

Physicochemical Properties

References

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