Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Bromodomain-IV-275
IV-275

Chemical Structure : IV-275

CAS No.:

Add to Favorites

IV-275 (IV 275)

Catalog No.: PC-21073Not For Human Use, Lab Use Only.

IV-275 is a next-generation inhibitor of BRG1 and BRM bromodomains, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IV-275 is a next-generation inhibitor of BRG1 and BRM bromodomains, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.
IV-275 only enhances TMZ-induced death in GBM cells that express the BRG1 subunit, has no such effect in BRG1KO GBM cells.
IV-275 increases the amount of DNA-damage induced by TMZ and bleomycin.
IV-275 (20 uM, 24h) inhibits cell invasion and IFN-induced gene expression in MT330 and LN229 GBM cells.
IV-275 reduces the IFN-induced expression of CXCl11, increases IFN-induced expression of STAT1, IRF1 and IRF7 in GBM cell lines.

Physicochemical Properties

M.Wt 360.36
Formula C19H18F2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N1[C@@](C2)([H])CN(C3=CC=C(OC)C=C3)[C@@]2([H])C1)OC4=CC=C(F)C(F)=C4

References

1. Chuanhe Yang, et al. J Cell Mol Med. 2023 Aug 18.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: