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IVA-337

Chemical Structure : IVA-337

CAS No.: 927961-18-0

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IVA-337 (Lanifibranor, IVA337)

Catalog No.: PC-61592Not For Human Use, Lab Use Only.

IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.

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10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
100 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IVA-337 (Lanifibranor, IVA337) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively.
IVA-337 (Lanifibranor, IVA337) reduces skin fibrosis in the mouse, and suppresses inflammation in vivo.

Physicochemical Properties

M.Wt 434.909
Formula C19H15ClN2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)butanoic acid

References

1. Ruzehaji N, et al. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.

2. Avouac J, et al. Ann Rheum Dis. 2017 Aug 11. pii: annrheumdis-2016-210821.

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