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Chemical Structure : Ibipinabant
Catalog No.: PC-20522Not For Human Use, Lab Use Only.
Ibipinabant (SLV319, BMS-646256) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor with Ki of 7.8 nM, >1000-fold selectivity for CB1 over CB2.
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Ibipinabant (SLV319, BMS-646256) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor with Ki of 7.8 nM, >1000-fold selectivity for CB1 over CB2.
SLV319 concentration dependently antagonizes WIN-55212 (CB1 agonist)-induced arachidonic acid release in CHO cells with pA2 of 9.9.
SLV319 (3 mg/kg/day; p.o. for 28 d) reduces the food intake, body weight, and hormonal/metabolic abnormalities in diet-induced obesity (DIO) mice.
SLV319 (3 mg/kg/day, p.o. for 28 d) reverses the HFD-induced increase in adipose tissue leptin mRNA.
SLV319 (3-10 mg/kg; daily oral gavage) has weight loss-independent antidiabetic effects and attenuates β-cell loss in a rat model of progressive β-cell dysfunction.
| M.Wt | 487.40 | |
| Formula | C23H20Cl2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lange JHM, et, al. J Med Chem. 2004 Jan 29;47(3):627-43.
2. Tam J, et, al. Cell Metab. 2012 Aug 8;16(2):167-79.
3. Rohrbach K, et, al. Diabetes Obes Metab. 2012 Jun;14(6):555-64.
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