Chemical Structure : Ibipinabant
CAS No.:
464213-10-3
Ibipinabant
(SLV-319, BMS-646256)
Catalog No.: PC-20522Not For Human Use, Lab Use Only.
Ibipinabant (SLV319, BMS-646256) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor with Ki of 7.8 nM, >1000-fold selectivity for CB1 over CB2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ibipinabant (SLV319, BMS-646256) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor with Ki of 7.8 nM, >1000-fold selectivity for CB1 over CB2.
SLV319 concentration dependently antagonizes WIN-55212 (CB1 agonist)-induced arachidonic acid release in CHO cells with pA2 of 9.9.
SLV319 (3 mg/kg/day; p.o. for 28 d) reduces the food intake, body weight, and hormonal/metabolic abnormalities in diet-induced obesity (DIO) mice.
SLV319 (3 mg/kg/day, p.o. for 28 d) reverses the HFD-induced increase in adipose tissue leptin mRNA.
SLV319 (3-10 mg/kg; daily oral gavage) has weight loss-independent antidiabetic effects and attenuates β-cell loss in a rat model of progressive β-cell dysfunction.
Physicochemical Properties
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M.Wt
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487.40
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Formula
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C23H20Cl2N4O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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C/N=C(N1N=C(C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC=C3)C1)/NS(=O)(C4=CC=C(Cl)C=C4)=O
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References
1. Lange JHM, et, al. J Med Chem. 2004 Jan 29;47(3):627-43.
2. Tam J, et, al. Cell Metab. 2012 Aug 8;16(2):167-79.
3. Rohrbach K, et, al. Diabetes Obes Metab. 2012 Jun;14(6):555-64.
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