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Ibulocydine

Chemical Structure : Ibulocydine

CAS No.: 1314096-68-8

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Ibulocydine

Catalog No.: PC-62682Not For Human Use, Lab Use Only.

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
    Ibulocydine reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis.
    Ibulocydine shows effectivity in HCC xenografts with no toxic side effects.

    Physicochemical Properties

    M.Wt 458.269
    Formula C16H20BrN5O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate

    References

    1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.

    2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.

    3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.

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